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Analytical methods including chromatographic methods are commonly used for the quantitative and qualitative analysis of raw materials, drug substances, drug products, and compounds in biological samples in pharmaceutical industry. The components monitored include chiral or achiral drugs, process impurities, residual solvents, excipients such as preservatives, degradation products, extractable and leachable from container and closure or manufacturing process, pesticide in drug product from plant origin, and metabolites. An advanced potentiometric electronic tongue and Sequential Injection Analysis (SIA) measurement system was applied for the quantitative analysis of mixtures containing three active pharmaceutical ingredients (APIs): acetaminophen, ascorbic acid and acetylsalicylic acid, in the presence of various amounts of caffeine as interferent
2D and 3D printing permits fabricating functional structures of metals, polymers, and biomaterials. 3D structures can be printed on a variety of surfaces with characteristic permeability, porosity, hydrophobicity/hydrophilicity and surface energy. This allows controlling the properties of the printed substances. Besides accurate patterning, printing on tailored functionalized substrates and multi-layer printing makes automated high-speed manufacture of complex structures possible. It opens up new avenues for tailoring physicochemical properties of organic substances. 3D-printing (3DP) is the art and science of printing in a new dimension using 3D printers to transform 3D computer aided designs (CAD) into life-changing products. This includes the design of more effective and patient-friendly pharmaceutical products as well as bio-inspired medical devices. It is poised as the next technology revolution for the pharmaceutical and medical-device industries. The 3D printing has become one of the most revolutionary and powerful tool serving as a technology of precise manufacturing of individually developed dosage forms, tissue engineering and disease modeling
Research in Pharmaceutical sciences has become multidisciplinary in nature and yielding a great benefit to the medical community and the society. The subject at present consists of numerous subjects in which Drug Delivery claims higher significance. Drug Delivery approaches have become multidisciplinary in nature and encompass a number of disciplines and sub disciplines within the broader scope of the topic. Various important topics including dosage forms, controlled release, drug absorption, ADMET, bioavailability, Nano medicine, Gene based delivery and therapy, drug designing and delivery, long term and short term impact of specific delivery issues, associated disease scenario, relation of drug delivery and diseases etc
Biopharmaceutics is defined as the study of factors that influencing rate and amount of drug which reaches the systemic circulation and use of this information to optimize the therapeutic efficacy of the drug products. The process of movement of drug from site of administration to systemic circulation is called as absorption. The concentration of drug in plasma, onset of action, intensity and duration of response depend upon the bioavailability of drug from its dosage form. Bioavailability is defined as the rate and extent (amount) of drug absorption which indicates active effect. The biological medical product indulges in manufacturing or extraction or semi synthesizing the pharmaceutical drug product from biological sources. The biologic drug is manufactured in all the living system such as plant cells or animal cells, or microorganism. Most of these biologics are produced with the help of Recombinant DNA technology.
Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. Gene therapy is a clinical therapeutic procedure in which genes are intentionally introduced into human somatic cells for turning on or restoring a gene function (gain of function) to produce a therapeutic protein with the desired action. Successful gene therapy requires a convenient and patient-acceptable route of gene administration, control over the location, functioning and expression of the administered gene, and formulation of a stable and safe gene product with high robustness and acceptable cost/risk–benefit ratio. Recent studies show substantial extracellular, intracellular, and biological barriers to the successful delivery of the therapeutic gene
Drug delivery describes the method and approach to delivering drugs or pharmaceuticals and other xenobiotics to their site of action within an organism, with the goal of achieving a therapeutic outcome. Issues of pharmacodynamics and pharmacokinetics are important considerations for drug delivery. Drug Delivery and Translational Research publishes research focused on such topics as designing and developing novel drug delivery systems, with a focus on their application to disease conditions; preclinical and clinical data related to drug delivery systems; short-term and long-term biocompatibility of drug delivery systems, host response; biomaterials with growth factors for stem-cell differentiation in regenerative medicine and tissue engineering; image-guided drug therapy; nanomedicine; devices for drug delivery and drug/device combination products
A few device, apparatus, application, software, material or other article, whether used only or in blend, together with any accessories, including the software intended by its manufacturer to be used specifically for diagnostic and/or therapeutic purposes. Next-generation drugs are pushing device developers to seek out and create new delivery methods, an expert tells MD+DI.We provide design expertise in developing innovative pharmaceutical devices for effective drug delivery including complex engineering design, high volume manufacturing knowledge and materials technology.
Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells. They exist functioning such as enzymes, hormones, structural element and immunoglobulin. The twenty different naturally occurring amino acids join with each other by peptide bonds and build polymers referred to peptides and proteins. Designing and formulating a polypeptide drug delivery through the gastro intestinal tract has been a persistent challenge because of their unfavorable physicochemical properties, which includes enzymatic degradation, poor membrane permeability and large molecular size. The main challenge is to improve the oral bioavailability from less than 1% to at least 30-50%. Consequently, efforts have intensified over the past few decades, where every oral dosage form used for the conventional small molecule drugs has been used to explore oral protein and peptide delivery
Pharmaceutical technology is application of scientific knowledge or technology to pharmacy, pharmacology, and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures and in the treatment of patients. Pharma Technology Focus is now available on all devices. Pharmaceutics is the discipline of pharmacy that deals with the process of turning a new chemical entity (NCE) or old drugs into a medication to be used safely and effectively by patients. It is also called the science of dosage form design. There are many chemicals with pharmacological properties, but need special measures to help them achieve therapeutically relevant amounts at their sites of action. Pharmaceutics helps relate the formulation of drugs to their delivery and disposition in the body
Smart Drug Delivery Systems (SDDS) have emerged as panacea for many clinically useful drugs weighed down with toxicity. The discovery of Amphotericin B as a liposome has raised hopes and directed mammoth efforts in SDDS. The concept of manipulation of toxicity has given rise to additional significant approaches like targeting and use of physico-chemical approaches. Currently the spectrum of SDDS comprises of targeting liposomes, drug loaded biodegradable microspheres, stimuli responsive drug polymer conjugates, smart hydrogels, polymeric micellar particles, intelligent lipoprotein carriers, and nano carriers. There is a wealth of knowledge accumulated worldwide in the area of SDDS, which can be extremely beneficial to industry as well as practitioners of health care. In this article an overview of developments are reviewed.