Challenges in Delivery of Therapeutic Genomics and Proteomics

Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. Gene therapy is a clinical therapeutic procedure in which genes are intentionally introduced into human somatic cells for turning on or restoring a gene function (gain of function) to produce a therapeutic protein with the desired action. Successful gene therapy requires a convenient and patient-acceptable route of gene administration, control over the location, functioning and expression of the administered gene, and formulation of a stable and safe gene product with high robustness and acceptable cost/risk–benefit ratio. Recent studies show substantial extracellular, intracellular, and biological barriers to the successful delivery of the therapeutic gene

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